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Tesi sperimentale
Effects of postnatal exposure to genistein in serotonergic brain circuits of male and female mice
Disponibile dal
NICO center (Neuroscience Institute Cavalieri Ottolenghi) in Orbassano
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Genistein is a phytoestrogen, particularly abundant in soybeans, that is able to bind estrogen receptors exerting

both estrogenic and anti-estrogenic activities. Due to the large use of soy-based feed (characterized by a high content of GEN) in farm animals, there are some concerns that this could alter some estrogen-sensitive neural circuits which may impair fertility rate, energetic metabolism, and decrease animal welfare. In the present study, we have

used an experimental protocol mimicking, in mice, the direct precocious exposure to GEN. Mice pups of both sexes were fed either with oil, estradiol or GEN from birth to postnatal day 8. Due to the fact that E2 is able to alter several neuroendocrine system, and that Serotonin has been implicated in practically every type of behavior, such as appetitive, emotional, motor, and sexual, our purpose is to analyze the effect of a estrogenic-like exposition in the serotonergic system.



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